Cage-Level Filter Testing

The presence of parasitic, bacterial, and viral infections in mouse colonies has been detected by polymerase chain reactions (PCR) in environmental samples such as exhaust air debris from individually ventilated caging (IVC) rack systems. Debris carried in exhaust air accumulates on inner surfaces of plenums or on filters placed within the path of exhaust airflow. However, not all IVCs are the same. Animal Care Systems' filtered caging system draws room air independently through each cage in a one-pass, laminar pattern. Room air is filtered at the inlet and exhaust of the cage before exiting into the central plenum. Cage dust containing infectious agents is captured on the cage exhaust filter as air passes through it. Study results show that cage exhaust filters detected infectious agents missed by dirty bedding sentinel testing, and is a valuable tool to include in your health monitoring program.

  • Removes the need to wash and autoclave rack plenums before every testing interval
  • Eradicates false positives from residual nuclei acid in previously contaminated plenums at earlier testing intervals
  • Reliably detects infectious agents from contaminated cages
  • Cage exhaust filters are in close and direct contact to the animals and bedding
  • Filters are very inexpensive and easy to remove for diagnostic submission
  • Multiple filters can be pooled and tested as one sample
  • More effective in detecting many infectious agents when compared to dirty bedding sentinels
  • Animals in dirty bedding cage can act as sentinels for adjunct testing using the hybrid approach
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