Identification of a Glycogen Synthase Kinase-3β Inhibitor that Attenuates Hyperactivity in CLOCK Mutant Mice
Validating GSK-3β as a relevant therapeutic target in the identification of new therapies for bipolar patients. Mice were housed in Optimice cages. Keywords: Transgenic, Mental Health, Addiction, Gene Expression, CLOCK gene, Bipolar disorder, C57BL/6J, Optimice, mouse, mice
Kozikowski, A. P., Gunosewoyo, H., Guo, S., Gaisina, I. N., Walter, R. L., Ketcherside, A., McClung, C. A., Mesecar, A. D. and Caldarone, B. (2011) Identification of a Glycogen Synthase Kinase-3β Inhibitor that Attenuates Hyperactivity in CLOCK Mutant Mice. ChemMedChem, 6: 1593–1602. http://onlinelibrary.wiley.com/doi/10.1002/cmdc.201100188/abstract
