R-Loops in Proliferating Cells but Not in the Brain: Implications for AOA2 and Other Autosomal Recessive Ataxias
R-loops constitute a novel trigger for genomic instability and the accumulation of these structures may represent an underlying and contributing mechanism in autosomal recessive ataxias characterised by defective responses to DNA damage. Mice were housed in Optimice cages. Keywords: Transgenic, Genetics, Gene Expression, R-Loops, DNA damage; mitochondrial function, neurodegenerative diseases, Optimice, mouse, mice
Abrey J. Yeo, Olivier J. Becherel, John E. Luff, Jason K. Cullen, Thidathip Wongsurawat, Piroon Jenjaroenpoon, Vladimir A. Kuznetsov, Peter J. McKinnon, Martin F. Lavin. R-Loops in Proliferating Cells but Not in the Brain: Implications for AOA2 and Other Autosomal Recessive Ataxias. PLoS ONE 9(3): e90219. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0090219
