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Effects of Female Sexual Chemosignals on Mucosal Immunity in BALB/c and C57BL/6 Male Mice
The sexual signals associated with infection risks provide genotype-dependent mobilization of the innate immunity without significant activation of physiological stress mechanisms. Mice were housed in Optimice cages. Keywords: Immune System, Immune response, female sexual chemosignals, lung mucosal immunity, Th1/Th2 immune balance, C57BL/6, BALB/c, Optimice, mouse, mice G. V. Kontsevaya, E. A. Litvinova, M. P. Moshkin.…
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Efficient Chimeric Mouse Production Using a Novel Embryonic Stem Cell LIne
Researchers need an embryonic stem cell line that is able to participate in the formation of chimeric animals even after prolonged cultivation in vitro. A novel DGES1 embryonic stem cell line was demonstrated to efficiently produce transgenic mouse using the B6D2F1 blastocysts and CD-1 recipients. Mice were housed in Optimice cages. Keywords: Transgenic, Genetics, Gene…
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Combined Effects of Individual Culture and Atmospheric Oxygen on Preimplantation Mouse Embryos in Vitro
Atmospheric oxygen and individual culture are standard embryo culture conditions, the effect of combining them when investigated shows that cleavage timings, hatching rates and blastocyst cell numbers were reduced by either individual culture or atmospheric oxygen. Mice were housed in Optimice cages. Keywords: Transgenic, Genetics, Cell Culture, Culture media, Embryology, Preimplanation, mouse embryo group culture,…
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Addition of Interleukin-6 to Mouse Embryo Culture Increases Blastocyst Cell Number and Influences the Inner Cell Mass to Trophectoderm Ratio
These data show that IL-6 improved mouse embryo development when cultured individually in complex media; however, an excess of IL-6 may be detrimental. Mice were housed in Optimice cages. Keywords: Transgenic, Genetics, Cell culture, Culture media, Cytokines, Embryology, Fertilization in vitro, Preimplantation, Optimice, mice, mouse Rebecca L Kelley and David K Gardner. Addition of interleukin-6…
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Behavioural Effects of Adult Vitamin D Deficiency in BALB/c Mice Are not Associated with Proliferation or Survival of Neurons in the Adult Hippocampus
This paper concludes that adult vitamin D deficiency was not associated with impaired proliferation or survival of adult born neurons in BALB/c mice and that the impact on rodent behaviour may not be due to altered neurogenesis per se, but to altered function of new hippocampal neurons or processes independent of adult neurogenesis. Mice were…
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Maternal Effects on Ethanol Teratogenesis in a Cross Between A/J and C57BL/6J Mice
This study supports the idea that genes influence malformation risk following in utero alcohol exposure. This research supports the conclusion that uterine environment contributes to determining risk of Fetal Alcohol Spectrum Disorder. Mice were housed in Optimice cages. Keywords: Fetal Alcohol Syndrome, Genetics, Extra-chromosomal inheritance, Drug-induced abnormalities, Mental Health, Addictions, Optimice, mice mouse David Gilliam,…
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Modulation of Embryonic Development Due to Mating with Immunised Males
The results emphasise the role of paternal effects of immune priming on the in utero environment and fetal growth. Mice were housed in Optimice cages. Keywords: Transgenic, Gene Expression, reproduction, pregnancy, paternal effect, ICR, C57BL/6, BALB/c, Optimice, mice, optimice, Genetics. Ludmila A. Gerlinskaya, Svetlana O. Maslennikova, Margaret V. Anisimova, Nataly A. Feofanova, Evgenii L. Zavjalov,…
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Cell-Type-Specific Expression of NFIX in the Developing and Adult Cerebellum
Data suggests that NFIX plays a role in regulating progenitor cell biology within the embryonic and post-natal cerebellum, as well as an ongoing role within multiple neuronal and glial populations within the adult cerebellum. Mice were housed in Optimice cages. Keywords: Transgenic, Genetics, Gene Expression, NFIX, cerebellum, C57Bl/6J, Optimice, mice, mouse, James Fraser, Alexandra Essebier,…
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Comparative Analysis of Pathologic Processes Developing in Mice Housed in SPF vs Non-SPF Conditions and Treated with Cyclophosphamide and dsDNA Preparation
CBA mice are treated with cyclophosphamide and fragmented exogenous dsDNA develop a very characteristic set of symptoms and 80–90% of such animals die within 6–25 days. Mice of the same strain housed under specific pathogen free (SPF) conditions do not develop the characteristic symptoms, nor do they become moribund. SPF mice were housed in Optimice…
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Low Density Lipoprotein-Receptor Related Protein 1 Is Differentially Expressed by Neuronal and Glial Populations in the Developing and Mature Mouse Central Nervous System
Data indicate that central nervous system glia are highly susceptible to regulation by low density lipoprotein-receptor related protein 1 (LRP1) signalling, a possibility that has been largely unexplored to date.. Mice were housed in Optimice cages. Keywords: Transgenic, Genetics, Gene Expression, lipoprotein metabolism, low density lipoprotein-receptor related protein 1, Optimice, mouse, mice Loic Auderset, Carlie…