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High Resolution Localization of Rab5, EEA1, and Nectin-3 to Tubulobulbar Complexes in the Rat Testis
This paper concludes that at tubulobulbar complexes in Sertoli cells of the seminiferous epithelium, the identity of ‘bulbs’ as putative early endosomes begins to be established prior to their undergoing scission or budding from their parent structures. Rats were housed in Optirat Plus cages. Keywords: Anatomy, Tubulobulbar complexes (TBCs) , sertoli cells,, anatomy, Reproductive, Optirat…
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Reproductive Effects of Tumor Necrosis Factor (TNF) Gene Knockout in Mice
This data should be taken into account when prescribing long-term anti-TNF therapy to patients of reproductive age. Mice were housed in Optimice housing. Keywords: Cancer, Immune System, Transgenic, Gene expression, Reproductive, Tumor necrosis factor, TNF, autoimmune diseases, Optimice, mice, mouse SO Maslennikov, GV Kontsevaya, MA Zolotykh, MV Anisimova, NA Feofanova, MP Moshkin, SA Nedospasov, LA…
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R-Loops in Proliferating Cells but Not in the Brain: Implications for AOA2 and Other Autosomal Recessive Ataxias
R-loops constitute a novel trigger for genomic instability and the accumulation of these structures may represent an underlying and contributing mechanism in autosomal recessive ataxias characterised by defective responses to DNA damage. Mice were housed in Optimice cages. Keywords: Transgenic, Genetics, Gene Expression, R-Loops, DNA damage; mitochondrial function, neurodegenerative diseases, Optimice, mouse, mice Abrey J.…
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Effect of Chronic Inhalation of Silicon Dioxide Nanoparticles (Tarkosil 25) On the Expression of Key Genes of the Serotonergic System in the Mouse Brain
The chronic inhalation of silicon dioxide nanoparticles does not activate nonspecific immunity in the brain, but it exerts contrasting genotype-specific effects on the expression of the 5-HT1A receptor in the hippocampus. Mice were housed in Optimice cages. Keywords: Silicon dioxide nanoparticles, specific pathogen-free mice, SPF, Tarkosil nanoaerosol, 5-HT1A receptor, environmental toxicity, Balb/c, C57Bl/6, Optimice, mouse,…
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Unexpected Phenotypic Effects of a Transgene Integration Causing a Knockout of the Endogenous Contactin-5 Gene in Mice
This paper reports a novel Cntn5 knockout mouse line generated by a random transgene integration as an outcome of pronuclear microinjection. Mice were housed in Optimice cages. Keywords: Metabolism, Transgenic, Gene Expression, insertional mutagenesis, Cntn5 deficiency, obesity, hypertension, C57BL/6 J, Optimice, Mouse, mice Alexander V. Smirnov, Galina V. Kontsevaya, Natalia A. Feofanova, Margarita V. Anisimova,…
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Morphophysiological Effects of Insertional Mutagenesis of the Contactin 5 (Cntn5) Gene in Transgenic Mice
The morphophysiological effects of integrating the transgenic construction providing the production of the human granulocyte–macrophage colony-stimulating factor in the milk of the mouse line (GM9) (the insertion of the construction in the intron of the contactin 5 (Cntn5) gene) isdescribed. Mice were housed in Optimice cages. Keywords: Metabolism, Transgenic, Gene Expression, insertional mutagenesis, fat metabolism,…
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Graft-Infiltrating PD-L1hi Cross-Dressed Dendritic Cells Regulate Antidonor T Cell Responses in Mouse Liver Transplant Tolerance “
The findings suggest that graft-infiltrating PD-L1hi CD-DCs may play a key role in the regulation of alloimmunity and in the induction of liver transplant tolerance.Mice were housed in Optimice cages. Keywords: Transgenic, Gene Expression, transplant rejection, liver transplant, organ transplant, C57BL/6, B6SJL-PtprcaPepcb/BoyJ, B6.Cg-Tg(Itgax-Venus)1Mnz/J, C3H/HeJ, Optimice, mouse, mice Ono, Y., Perez-Gutierrez, A., Nakao, T., Dai, H.,…
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Postnatal Development of the Craniofacial Skeleton in Male C57BL/6J Mice
For C57BL/6J male mice, postnatal day 60 is the earliest time point at which the skull achieves its adult shape and proportions. In addition, C57BL/6J male mice appear to have an inherent susceptibility to craniofacial malformation. Mice were housed in Optimice cages. Keywords: Anatomy, C57BL/6J, postnatal development, Optimice, mouse, mice Murat Maga, A. Postnatal Development…
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Food Deprivation Increases Hepatic Hepcidin Expression and Can Overcome the Effect of Hfe Deletion in Male Mice
These results indicate that Hamp1 induction by food deprivation is independent of HFE and suggest that targeting the pathway regulated by food deprivation could have clinical benefit in iron loading conditions. Mice were housed in Optimice cages. Keywords: Nutrition, Nutrional deficiencies, Transgenic, Gene Expression, food deprivation, hereditary hemochromatosis, Optimice, mouse, mice Cornel S. G. Mirciov,…
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Identification of a Glycogen Synthase Kinase-3β Inhibitor that Attenuates Hyperactivity in CLOCK Mutant Mice
Validating GSK-3β as a relevant therapeutic target in the identification of new therapies for bipolar patients. Mice were housed in Optimice cages. Keywords: Transgenic, Mental Health, Addiction, Gene Expression, CLOCK gene, Bipolar disorder, C57BL/6J, Optimice, mouse, mice Kozikowski, A. P., Gunosewoyo, H., Guo, S., Gaisina, I. N., Walter, R. L., Ketcherside, A., McClung, C. A.,…