A class of environmental compounds derived from dietary, microbial, and industrial sources that induce CD1d-dependent intestinal inflammation is identified, that are potentially associated with Intestinal Bowel Disease. Colitis experiments, were performed in Optimice cages under sterile conditions. Keywords: Microbiome, Gut Microbiota, Inflammatory Bowel Disease, Colitis, Transgenic, Gene Expression, Optimice, Mice, Mouse Shankar S. Iyer, Thomas…

Outbred CD1 mouse colonies with stable, complex gut microbial profiles were produced to be used as donors for a variety of GM transfer techniques. Cohorts of these developed colonies were send to collaborating institutions, one of which uses Optimice caging. Keywords: Gnotobiotic, Microbiome, Gut Microbiota, Optimice, CD-1, Mice, Mouse. Hart, Marcia L; Ericsson, Aaron C;…