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Maternal Effects on Ethanol Teratogenesis in a Cross Between A/J and C57BL/6J Mice
This study supports the idea that genes influence malformation risk following in utero alcohol exposure. This research supports the conclusion that uterine environment contributes to determining risk of Fetal Alcohol Spectrum Disorder. Mice were housed in Optimice cages. Keywords: Fetal Alcohol Syndrome, Genetics, Extra-chromosomal inheritance, Drug-induced abnormalities, Mental Health, Addictions, Optimice, mice mouse David Gilliam,…
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Modulation of Embryonic Development Due to Mating with Immunised Males
The results emphasise the role of paternal effects of immune priming on the in utero environment and fetal growth. Mice were housed in Optimice cages. Keywords: Transgenic, Gene Expression, reproduction, pregnancy, paternal effect, ICR, C57BL/6, BALB/c, Optimice, mice, optimice, Genetics. Ludmila A. Gerlinskaya, Svetlana O. Maslennikova, Margaret V. Anisimova, Nataly A. Feofanova, Evgenii L. Zavjalov,…
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Cell-Type-Specific Expression of NFIX in the Developing and Adult Cerebellum
Data suggests that NFIX plays a role in regulating progenitor cell biology within the embryonic and post-natal cerebellum, as well as an ongoing role within multiple neuronal and glial populations within the adult cerebellum. Mice were housed in Optimice cages. Keywords: Transgenic, Genetics, Gene Expression, NFIX, cerebellum, C57Bl/6J, Optimice, mice, mouse, James Fraser, Alexandra Essebier,…
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Comparative Analysis of Pathologic Processes Developing in Mice Housed in SPF vs Non-SPF Conditions and Treated with Cyclophosphamide and dsDNA Preparation
CBA mice are treated with cyclophosphamide and fragmented exogenous dsDNA develop a very characteristic set of symptoms and 80–90% of such animals die within 6–25 days. Mice of the same strain housed under specific pathogen free (SPF) conditions do not develop the characteristic symptoms, nor do they become moribund. SPF mice were housed in Optimice…
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Low Density Lipoprotein-Receptor Related Protein 1 Is Differentially Expressed by Neuronal and Glial Populations in the Developing and Mature Mouse Central Nervous System
Data indicate that central nervous system glia are highly susceptible to regulation by low density lipoprotein-receptor related protein 1 (LRP1) signalling, a possibility that has been largely unexplored to date.. Mice were housed in Optimice cages. Keywords: Transgenic, Genetics, Gene Expression, lipoprotein metabolism, low density lipoprotein-receptor related protein 1, Optimice, mouse, mice Loic Auderset, Carlie…
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Dietary and Microbial Oxazoles Induce Intestinal Inflammation by Modulating Aryl Hydrocarbon Receptor Responses
A class of environmental compounds derived from dietary, microbial, and industrial sources that induce CD1d-dependent intestinal inflammation is identified, that are potentially associated with Intestinal Bowel Disease. Colitis experiments, were performed in Optimice cages under sterile conditions. Keywords: Microbiome, Gut Microbiota, Inflammatory Bowel Disease, Colitis, Transgenic, Gene Expression, Optimice, Mice, Mouse Shankar S. Iyer, Thomas…
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Development of Outbred CD1 Mouse Colonies with Distinct Standardized Gut Microbiota Profiles For Use in Complex Microbiota Targeted Studies
Outbred CD1 mouse colonies with stable, complex gut microbial profiles were produced to be used as donors for a variety of GM transfer techniques. Cohorts of these developed colonies were send to collaborating institutions, one of which uses Optimice caging. Keywords: Gnotobiotic, Microbiome, Gut Microbiota, Optimice, CD-1, Mice, Mouse. Hart, Marcia L; Ericsson, Aaron C;…
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Lean Six Sigma: Reducing Mouse Cage Sanitation Time by Dr David W. Brammer and Dr Jamison V. Kovach
The cage sanitation process for animals used in biomedical research can be labor-intensive.Procedures are described in this paper that resulted in reduction of the average mouse cage sanitation process cycle time by 35 min, and the time saved was reinvested within the ACO to provide technicians additional time to complete other valuable tasks and thus…
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A Stitch in Time Saves Nine by Dr. David Brammer
The use of ventilated cages for housing rats and mice is a well-recognized method to prevent infectious diseases from spreading throughout the animal facility. There are multiple designs for the placement of cages on ventilated racks, but the unique design of both the Optimice caging and Optirat caging allows the efficient movement of cages through…
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Bugs in the Mouse House-Expanding the Use of Arthropods in Biomedical Research by Dr. Bradley Ahrens
As the scientific community strives to reduce, refine, and replace animals used in research, there is an increasing demand to develop viable alternative models to meet the growing needs of modern science. To this end, invertebrate models are becoming increasingly prevalent, and present a useful alternative to mammals for studying human disease. To many, they…